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TWN Info Service
on Health Issues (April 11/01) Smallpox Stocks Are Not National Assets For more than a decade, the World Health Assembly’s
determination to destroy remaining smallpox virus stocks has been frustrated
by the refusal of the As this informational briefing explains, the remaining
smallpox stocks are actually an international resource that was collected
and entrusted to the World Health Organization (WHO) many years ago
that is now stored in the Because the stocks are an international asset
created by a multilateral effort under the auspices of the WHO, Member
States of the WHO need not defer to the The upcoming WHA (16-24 May, 2011) will be discussing the issue of smallpox destruction once again. More information can be found at www.smallpoxbiosafety.org With best wishes,
Smallpox InfoBrief #1 Written
by Edward Hammond for the and smallpoxbiosafety.org, April 2011 First in a series of short informational briefings on the issue of destruction of smallpox virus stocks Smallpox stocks do not belong to the United States or Russia For more than a decade, the World Health Assembly’s
determination to destroy remaining smallpox virus stocks has been frustrated
by the refusal of the The perception that these stocks are national
assets of the As the natural incidence of smallpox declined
in the 1960s and 70s through WHO eradication efforts, the leaders of
the WHO Smallpox Eradication Program recognized that laboratory accidents
were an increasingly dangerous potential source of new outbreaks. In
1973, a worker at the London School of Hygiene and Tropical Medicine
became infected. Although she survived, two visitors to the hospital
where the worker was initially confined contracted smallpox and died.
Two years later, in 1975, a smallpox-infected chimpanzee escaped from
a Such problems helped spur the WHA to act to reduce the number of labs holding smallpox stocks to an absolute minimum because minimizing smallpox stocks was pivotal to ensuring that the disease did not escape from a lab. In 1976, WHA Resolution 29.54 urged labs to destroy any unnecessary stocks[3] and asked the Director-General to consult with the Committee on International Surveillance of Communicable Diseases on future retention of variola (smallpox) viruses. In 1977, the Committee on International Surveillance of Communicable Diseases returned a recommendation that “stocks of variola viruses be retained only by WHO Collaborating Centres”. The recommendation was endorsed by the Executive Board (EB59.R28), and by the WHA in 1977 in Resolution 30.52. A year later, the WHA reinforced its position, resolving in WHA31.54 (1978) that it “Requests all laboratories except WHO collaborating centres to destroy or transfer their remaining stocks to a collaborating centre”.[4],[5] WHO’s attempt to identify remaining laboratory stocks had been ongoing since at least 1975. In 1976, Member States were requested through the WHO Regional Offices to identify labs holding the virus. The labs that were identified were requested to either destroy their stocks or to transfer them to a WHO Collaborating Centre. In addition to the WHA Resolutions in 1976, 1977
and 1978, in August 1978, yet another accident lent new imperative to
the WHO’s effort. At the By late 1978, all WHO Member States and territories
(except By 1983, the process came to the point at which
it remains today, with all stocks either destroyed or transferred to
WHO Collaborating Centres in the Available WHO records do not distinguish between
those Thus, while the Collaborating Centres in Russia and the United States have been the sole virus repositories for 28 years, the current locations of the virus stocks does not change the fact that the viruses were transferred to WHO Collaborating Centres under the auspices of WHA resolutions and the WHO Smallpox Eradication Program. To this day, provided that relevant safety conditions can be met, there is no fundamental reason why a WHA resolution could not replace the Russian or United States labs with a new WHO authorized repository to manage the virus stocks.[10] Thus, in summary, despite the location of the
two WHO authorized repositories, neither the Because the stocks are an international asset
created by a multilateral effort under the auspices of the WHO, Member
States of the WHO need not defer to the The 1970s WHO documents cited in this briefing may be accessed online at: http://www.smallpoxbiosafety.org/resources.html [1]
Smallpox virus stocks now exist solely at the WHO Collaborating Centres
at the Centers for Disease Control and Prevention (CDC), [2]
Tucker J. 2001. Scourge. Grove Press. [3] Fenner F et al. 1988. Smallpox and its Eradication. WHO. p. 1339. [4] WHO 1979. Report of Meeting of Officials from Laboratories Retaining Variola Virus and National Control Authorities Concerned. WHO/SE/79.137. [5] WHO 1979. The Achievement of Global Eradication of Smallpox. Final Report of the Global Commission for the Certification of Smallpox Eradication. December. WHO/SE/79.152 [6]
WHO 1979. Laboratories with Variola Virus Stocks. WHO/SME/78.46. At
the time, the Japanese Collaborating Centre was constructing a new laboratory
facility. The transfer to the US Collaborating Centre was called temporary.
It does not appear, however, that the stocks were ever returned to [7] Fenner F. 1988. p. 1340. [8]
“Risk is directly related to the number of laboratories maintaining
variola virus stocks. It was recommended that only the WHO Collaborating
Centres for Poxvirus Research and the WHO Collaborating Centre for Smallpox
Vaccine (herein after called WHO Centres) be repositories of variola
virus and this number should be subject to periodic review.” WHO.
1977. Report of a Workshop on Safety Measures in Laboratories Retaining
Variola Virus. WHO/SME/77.2. Although a Centre in the [9] This list is not a final compilation. It is based upon WHO. 1977. Progress Report on Register of Laboratories Retaining Variola Virus. WHO/S2/180/3. [10] This is not suggested as a practical course of action. Rather, the example is presented to illustrate the WHA’s unexercised potential to control the virus stocks.
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